Rebecca Taylor of Mary Meets Dolly seems to have posted the story first. (I fell behind on my blog reading, so I am just coming across it now.) Dr. Mehmet Oz, who is both an eminent heart surgeon and Columbia Medical School professor and a pop health celebrity and Oprah darling, told Michael J. Fox to forget about embryonic stem cells.



Dr. Oz said, "I think the stem cell debate is dead.... The problem with embryonic stem cells is that ... it's very hard to control them, and they can become cancer.... In the last year we've made ten years of advancement" on induced pluripotent stem cells.

Embryonic stem cells have turned out to be wild horses. They are too flexible. Induced pluripotent stem cells are recently developed technology that uses a patient's own body cells. They do not cause an immune response in the patient and they do not require the killing of anyone, embryo or adult.

It turns out, in the stem cell debate, that you can have your cake and eat it too: you can have pluripotent stem cells, and you can have them ethically.


Animals and Catholics series will continue soon, I promise.

My stem cell articles for Bright Hub for March have been published. There are some articles about treatments. If you only read one, read the one about induced pluripotent stem cells (iPSCs). These show incredible promise as a controvery-free replacement for embryonic stem cells.

• Induced Pluripotent Stem Cells (iPS cells)
• Problems With Embryonic Stem Cell Treatments
• Stem Cell Treatments for Paralysis (both embryonic stem cells and adult stem cells)
• The Cutting Edge of Stem Cell Research — amazing advances with adult stem cells

Stem cell research is moving so fast that it is hard to keep up. Already there are clinical trials that may actually heal spinal cord injuries. Unfortunately, they use embryonic stem cells. Amazingly, embryonic stem cells may not even be necessary for this treatment; adult stem cells have healed spinal cord injuries in rats, just like embryonic stem cells.

President Barack Obama is rescinding the U.S. ban on research on new lines of embryonic stem cells. The narrative that his administration is promoting is that this research is "pro-science," and that the Bush ban on such research was "anti-science" due to ignorance about the potential of stem cells. To strengthen the narrative, the propagandists seek intentionally to confuse the difference between the two major types of stem cells used in research.

Therapies using so-called "adult" stem cells, which can be obtained without significant harm to the donor, show great promise as potential treatments for diseases from heart disease to diabetes. Embryonic stem cells, which are obtained only after killing the human donor, have so far proven to be more problematic, as they have a tendency to form tumors called teratomas.

Julia Dory Ransohoff, a 17-year-old prodigy who has conducted her own stem cell research, has appeared in the news as a finalist for the Intel Science Talent Search. She was invited to meet the President as part of the pro-embryonic stem cell research propaganda effort.

But here's the "lie," which is actually an omission meant to confuse: Ms. Ransohoff's research is not on embryonic stem cells at all. She used adult stem cells from bone marrow. She found that heterologous stem cells to treat heart disease elicit a greater immune response for female donors than for male donors (that's the "sex").

The tactic used by supporters of embryonic stem cell research is to cloud the ethical questions surrounding it by failing to distinguish between embryonic and adult stem cells. There is no serious ethical opposition to the use of adult stem cells. Bioethicists from all sides of the debate agree on that point. Failing to make the distinction is dishonest and dishonorable.

Image: Mouse dendritic cells (a type of immune system cell) derived from bone marrow adult stem cells. Source: National Cancer Institute.

Update: After I published this post, I saw this headline: "Obama moves to separate politics and science." Just as I said, the Obama administration is trying to paint the issue as one of noble science v. extremist politics, rather than as an ethical debate.

You may know that I write science articles for the a science and technology website called Bright Hub. I just completed a short series on the basics of stem cells: terminology, classification, and sources. Each article is meant to stand alone, so they are a little repetitive.

These are not opinion pieces, so I did not express my personal strenuous opposition to any use of embryonic stem cells. I did carefully note in every article in which embryonic stem cells are mentioned that harvesting embryonic stem cells kills the embryo.

Only one article is about stem cell treatments. That's because I was only assigned to write one. Here are the links:

• Facts about stem cells
• Types of stem cells
• How stem cells are harvested
• Cloning and stem cells
• Heart disease treatment with stem cells

Would you like to see me write more about stem cells? Are there any particular topics you would like to see covered? I can always write as much as I like in this space, and I can ask my editor for more stem cell assignments at Bright Hub.

If you read any of the many blogs or news sources that deals with bioethics, then you will have heard of the story from the BBC that a British fertility doctor has successfully performed eugenics via in vitro fertilization. He tested embryos for a gene that is associated with an increased risk of breast cancer, and implanted only those embryos that were pure enough to meet his standards; the rest were killed (euphemistically, "discarded"). What was really remarkable about the story was the ridiculous attempt to redefine standard medical terminology to make the act more palatable. Conception is synonymous with fertilization, but the BBC parroted the doctor in incorrectly claiming that conception is actually synonymous with implantation. This allows the doctors to pretend that the genetic test took place before any human individuals were created by saying it was "pre-conception." For more information, see this post on the blog Mary Meets Dolly.

For the benefit of readers who may encounter mendacious doctors and scientists who deal with beginning-of-life issues, here is a glossary of related terms:

abortifacient

A drug or other substance that induces an abortion. Abortifacients may cause expulsion of the embryo or fetus, killing it, or they may prevent the implantation of an embryo. In the narrowest clinical sense, the latter is not technically the termination of a pregnancy, but it does result in the killing of the embryo.

abortion

The termination of a pregnancy; usually used for terminations before about 20 weeks gestation. Abortions may be spontaneous and natural (in which case they are also called miscarriages) or intentional (in which case they are also called induced abortions). An abortion always results in the death of the embryo or fetus.

adult stem cell

Any stem cell derived from an individual after the embryonic stage of development. Despite the name, they can be obtained from fetuses, umbilical cords, and children as well as from adults. Adult stem cells vary widely in potency. They can be obtained without injuring the donor.

baby

A non-scientific, non-specific term referring to a young human individual. Depending on context, it can refer to a zygote, embryo, fetus, newborn, or older child. Obstetricians routinely refer to embryos and fetuses as "babies" when the pregnancy is wanted, but not if the mother intends to abort the pregnancy. See abortion.

chromosome

A unit of genetic material. Every species has a fixed number of chromosomes.

conception

Synonymous with fertilization.

diploid

Having two copies of each chromosome per cell. In mammals, all cells except gametes are diploid.

egg

Also called an ovum, a female gamete. In humans, eggs are very large cells that are usually produced one at a time.

embryo

An organism from the time of the first cell division to a set point such as birth or hatching. In humans, an individual from the first cell division after conception until eight weeks after conception (ten weeks gestation), at which point it is called a fetus.

embryonic stem cell

A stem cell taken from an embryo. Embryonic stem cells are pluripotent, meaning they can differentiate into almost any tissue type. They are obtained by removing the embryo's inner cell mass, killing the embryo.

eugenics

The practice of attempting to improve the human race by either killing individuals perceived as genetically inferior, preventing such individuals from reproducing, or encouraging increased reproduction for individuals perceived as superior.

fertilization

The union of a haploid egg and a haploid sperm, resulting in a new, independent diploid individual. Fertilization naturally takes place in a woman's Fallopian tube after sperm are introduced through sexual intercourse.

fetus

In humans, an individual from eight weeks after fertilization until birth. A fetus that is near term is indistinguishable from a newborn except in certain physiological characteristics that change at birth, such as the closing of a blood vessel called the ductus arteriosus.

gamete

A haploid reproductive cell whose role is to unite with an opposite-sex gamete to create a new individual. Also called sex cells, they consist of eggs and sperm.

haploid

Having one copy of each chromosome per cell. In mammals, only gametes are haploid; all other cells are diploid.

implantation

The point at which an embryo, at the age of a few days in humans, becomes attached to the lining of the uterus.

in vitro fertilization

Fertilization that takes place outside the human body ("in vitro" literally means "in glass"). In vitro fertilization removes the sex act from reproduction. The zygotes are allowed to develop for several days into embryos, at which time one (or more) is placed inside the mother's body in the hope that it (or they) will undergo implantation, resulting in pregnancy. For practical reasons, it involves the fertilization of multiple zygotes, almost always more than can ever be implanted.

miscarriage

Also called spontaneous abortion, the unintentional termination of a pregnancy as a result of natural causes or, less commonly, accident.

newborn

Also called a neonate, an individual who has very recently been born. A newborn is indistinguishable from a late-term fetus except in certain physiological characteristics related to the loss of the placenta.

pregnancy

In mammals, including humans, the carrying of one or more embryos or fetuses in the uterus. In clinical terms, pregnancy begins at implantation, though the embryo exists as a separate individual in the mother's body before implantation. Thus pregnancy begins after the beginning of an individual human life.

sperm

A male gamete. In humans, sperm are small, motile cells that are produced daily in very large numbers by men's bodies.

stem cell

A cell capable of reproducing indefinitely, and usually capable of developing into one of several types of tissue. Stem cells are classified by "potency," that is, how many different types of tissue they can become. Stem cells are found in developing embryos, in umbilical cords, and in various other tissues such as bone marrow.

zygote

A brand-new, single-celled individual from fertilization until the first cell division, at which point it is called an embryo. The zygote stage in humans is very brief; it experiences the first cell division and becomes an embryo even before implantation.

Scientific American recently interviewed U.S. Congresswoman Diana DeGette (D-Colorado) about her new book, Sex, Science, and Stem Cells. DeGette's book decries opposition to her favorite political pets, those related to human reproduction. Her thesis that this opposition constitutes an attack against science itself is an appalling lie, in which SciAm is blithely complicit. (It's not the only publisher so inclined; "Science and Religion News" glowingly praised the interview.)

The trouble starts right with the title of the interview: "Congresswoman Slams Religious Right's Assault on Science's 'Edgier' Side." "Edgy"? To many scientifically literate people, embryonic stem cell research (ESCR) is vivisection writ very small. Something that unethical can hardly be described with the benign adjective "edgy."

What began in the title grows worse throughout the article. On the second page of the online article, the interviewer asks, "Why did you choose to focus on what you call the "edgier-side" of the big antiscience conspiracy?" This is a classic loaded question, an informal logical fallacy, which makes SciAm's political position crystal clear. Let me refute the assumption behind this question here:

There is no big antiscience conspiracy. The Bush administration is not whispering together with other opponents of (ESCR), "How can we stymie science? Let's count the ways!" In fact, I think one would be hard-pressed to identify even one ESCR opponent who also opposes research that does not involve destroying human beings.

There is no assault against science. Rather, the assault is against particular forms of scientific research that are unethical. ESCR is in the same category as the notorious Tuskegee Study.

ESCR is not about sex. It's about human life: the lives of embryos and the lives of sick people hoping for cures. Research ethics forbid allowing the potential for medical cures to trump the rights of research subjects. It would be just as unethical even if adult stem cell research did not offer potential cures without the ethical thorns.

DeGette declares, "I'm pro-science." She seems to be trying to recouch language to denigrate her opponents, the same way abortion-rights supporters did when they coined the noxious term "anti-choice." There is an implicit lie in DeGette's rhetoric: If you disagree with her political views on ESCR, then you are "antiscience." SciAm should dispense with perpetuating this mendacity and pay no more attention to DeGette.